TERT anticorps

N° du produit ABIN6945141

Cet anticorps Lapin Monoclonal détecte spécifiquement TERT dans WB et FACS. Il présente une réactivité envers Humain.

Aperçu rapide pour TERT anticorps (ABIN6945141)

Antigène: TERT (Telomerase Reverse Transcriptase (TERT))

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp TERT est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS)

Clone: 1C1

Détail du produit anti-TERT anticorps

Réactivité croisée: Humain

Purification: Purified by Protein A.

Immunogène: Human Telomerase reverse transcriptase between 1100 to 1200 amino acids

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
FCM 1:20-100

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur TERT

Antigène: TERT (Telomerase Reverse Transcriptase (TERT))

Autre désignation: Telomerase reverse transcriptase

Sujet:

Synonyms: Telomerase reverse transcriptase, HEST2, Telomerase catalytic subunit, Telomerase-associated protein 2, TP2, TERT

Background: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis.

ID gène: 7015

UniProt: O14746

Pathways: Telomere Maintenance